SUMMARYDuring fiscal year 2018, the NCI awarded a total of 1,162 competing Research Project Grants (RPGs), which represented an overall success rate of 11% for all RPGs and 12% for unsolicited R01s. More unsolicited R01 awards were made in 2018 than in 2017, but the overall R01 success rate decreased somewhat compared with 2017 because there was an 11% increase in the number of unsolicited R01 grant applications in 2018. Unsolicited R01 and R21 grants represent 74% of the total number of awards for 2018. NCI funded nearly all R01 applications with scores up to and including the 9th percentile and R21 applications with scores up to and including the 7th percentile. Special consideration was given to support funding for Early Stage R01 Investigators; as a result, almost all applications in this group with scores up to and including the 14th percentile were funded. The R03 and R15 applications with impact scores up to and including a score of 25 were funded. NCI funded applications with scores beyond the payline after review and approval by NCI?s Divisions and Scientific Program Leaders during special meetings with the NCI Director. The graphs that appear below summarize the overall funding patterns for R01s and R21s across various categories of investigators.
NCI introduced the R35 Outstanding Investigator Award (OIA) in fiscal year 2015, to support investigators with outstanding records of productivity in cancer research by providing extended funding stability for projects of unusual potential. OIA recipients are required to relinquish their current R01 awards in accepting the OIA and to commit at least 50% effort to the OIA research. NCI will only consider funding two additional research project grants to the Outstanding Investigator while the OIA is active. This limit includes single PD/PI, multiple PD/PI and multi-project grants. This policy could potentially lead to possibly leading to a reduction in the number of R01s over time.
- - FY 2018 R01
- - FY 2018 R21
- - Table 1: Fiscal Year 2017: Success Rates (unsolicited R01s and R21s)
- - Table 2: All Competing Research Project Grants
- - Comments
Funding Patterns for R01 Applications
The graph in Figure 1 summarizes the number of percentiled R01 applications received and grants funded at each percentile, among all investigators. As expected, beyond the 9th percentile, the number of grants funded decreased in proportion to the percentile ranking. Nevertheless, 15.7% of these awards had rankings beyond the 9th percentile.
Similar displays are shown below for experienced investigators (applicants who have received a prior R01 award and were applying for a new grant or a competitive renewal; Figure 2); new investigators (Figure 3); and early stage investigators (Figure 4). Similar patterns are observed in all cases. Success rates have not been plotted for new and early stage investigators because of the small numbers of applications at each percentile score. For Success Rate comparisons, refer to Tables 1 and 2 below.
Funding Patterns in previous years are posted at: https://gsspubssl.nci.nih.gov/blog/articles.
 The success rate is the percentage of applications received that are funded. It is calculated by dividing the number of funded grants by the number of applications received. When an amended application is considered in the same fiscal year as the original, only the application with the better score is counted in the number of applications received.
 A percentile is a score that ranks competing applications against others in the same study section in the past year. It is intended to allow a comparison of impact scores of applications across all study sections.
 The New Investigator is one who has not previously competed successfully for an R01 or other substantial NIH independent research award. An Early Stage Investigator is a New Investigator who is within 10 years of completing his/her terminal research degree or medical residency (or the equivalent). A more detailed definition can be found at: https://grants.nih.gov/policy/new_investigators/index.htm#definition.
 The impact score is given by each individual scientific reviewer's assessment of the scored criteria plus additional criteria regarding the protection and inclusion of human subjects; vertebrate animal care and welfare; biohazards, and criteria specific to the funding opportunity and is based on the overall impact that the project is likely to have on the research field(s) involved.
NCI FY2018: "Percentiled" R01 Applications, Awards and Success Rates
Figure 1: All Investigators: Experienced, New and Early Stage
NCI FY2018 Competing R01 Applications and Awards
Figure 3: New Investigators (Includes Early Stage Investigators)
Figures 1-4: Excludes applications that did not receive a percentile ranking. When an amended application is considered in the same fiscal year as the original, only the one with the better ranking is counted.
Funding Patterns for R21 Applications
The funding patterns for R21 grant applications differ from those of R01 applications. The patterns are explained by the fact that NCI receives a disproportionate number of applications relative to the number of R21 grants that can be funded (see Table 1). Of the Competing R21s funded, 10.7% had rankings beyond the 7th percentile. percentile. The number of R21 applications decreased in FY 2017, as NCI no longer has an R21 omnibus FOA and does not accept unsolicited R21s.
In contrast to R01 funding patterns, success rates for R21 funding of applications from new investigators (applicants who have never received an R01; Figure 7) is 8%, which is notably lower than the 11% success rate for experienced investigators (applicants who have received a prior R01 award; Figure 6) (Table 1). This disparity results from the fact that R01 applications, but not R21 applications, from early stage investigators are given preferential consideration. As explained in footnote 3 above, early stage investigators are new investigators within 10 years of receiving their highest degree or completing their clinical training who have not had an R01 award or other substantial NIH independent research award; Figure 8. Although R21 success rates for new investigators are lower than for experienced investigators, new investigators received a majority of the R21 awards.
NCI FY2018: R21 Applications, Awards and Success Rates
Figure 5: All Investigators: Experienced, New and Early Stage
NCI FY2018 Competing R21 Applications and Awards
Figure 7: New Investigators (Includes Early Stage Investigators)
NCI applied the same R01 criteria to identify new and early stage investigators. For Success Rate comparisons, refer to Tables 1 and 2 below.
Figures 5-8: Excludes applications that did not receive a percentile ranking. When an amended application is considered in the same fiscal year as the original, only the one with the better ranking is counted.
Table 1: Fiscal Year 2018: Success Rates (unsolicited R01s, R37s and R21s)
|Total Applications||Number With Percentiles
|Number With Percentiles
|R01/R37 - All Investigators||5,864||1,506||575||676||12%|
|Experienced Investigators - Total||4,180||1,130||445||488||12%|
|Type 3 Board||24||6||2||2||8%|
|New Investigators - Total1||1,684||376||130||188||11%|
|Early Stage New Investigators2||668||182||71||117||17%|
|R21 - All Investigators||2,100||569||227||187||9%|
|Early Stage New Investigators2||322||76||27||27||8%|
Total new and competing renewal applications include those that received either a percentile, an impact score, as well as those that were not discussed (triaged) or were not recommended for funding.
Funded R01s include competing revisions. In FY18 64 R01s were converted to R37s.
1 Includes Early Stage Investigators
2 Included in New Investigators
The NIH does not report the R21 grants in terms of experienced and new investigators; NCI applied R01 criteria to identify those parameters.
Table 2: All Competing Research Project Grants
|FY 2014||FY 2015||FY 2016||FY 2017||FY 2018|
|Requested||Funded||Success Rate||Requested||Funded||Success Rate||Requested||Funded||Success Rate||Requested||Funded||Success Rate||Requested||Funded||Success Rate|
|R01/R37 - Unsolicited1||3,849||578||15%||4,550||623||14%||4,785||650||14%||5,263||650||12%||5,864||676||12%|
|R21 - Unsolicited||2,539||302||12%||2,864||325||11%||3,100||260||8%||1,513||109||7%||2,100||187||9%|
|R03 - Unsolicited||627||93||15%||582||67||12%||484||48||10%||714||90||13%||564||60||11%|
|Total Competing RPGs:||8,539||1,207||14%||9,525||1,236||13%||10,241||1,230||12%||9,704||1,139||12%||10,317||1,162||11%|
1 Funded R01s include competing revisions. In FY2018 64 R01s were converted to R37s.
2 Other RFAs include UM1, R33, R38, P01, U01, UH2, and UG3.
3 Other RPGs include S12, DP2, P01, R15, R50, R56, R00, U01, U19, UH2, UH3, R33, UM1, and UG3.